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[Q] Can I designate the entire USA as a regional center area?
Good try, but USCIS has rarely even approved the entire single state as a regional center, although it has done so in a few occasions. One legal reason for this is that the regulations require the regional center area to be "contiguous" area. A practical reason might be that USCIS just doesn't want to allow the entire USA to be a regional center area, although I must admit there is no per se legal reason why USCIS cannot approve the entire USA as a single regional center geographic region.
I actually think USCIS make it easy on themselves and allow the entire USA to be a regional center geographic area in certain cases where projects are likely to arise all across the USA. It would be a waste of time to force the regional center applicant to file the same application for each state.